Liver: Function and dysfunction in COVID-19

Liver: Function and dysfunction in COVID-19

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Context: COVID-19 is known to cause extrapulmonary manifestations, including gastrointestinal and abnormal liver afunctions.Multiple mechanisms have been proposed to explain the pathobiology of liver damage: ACE2 receptor cholangiocytes mediated systemic inflammation, cytokine storm, hyperinflammation, and hypoxic changes.This was a cross-sectional study done in Department of General Medicine,JJM Medical College Davangere between July and September 2020 of patients falling under Category B and Category C.Materials and Methods: The aim is to describe the clinical characteristics in patients of click here COVID-19 and investigate the gender difference with particular regard to liver impairment.

Confirmation of COVID-19 positivity was based on RT-PCR for SARS-CoV-2 RNA.Laboratory investigations and clinical data was analyzed using SPSS Statistics 27.Results: The final study population consisted of 116 patients.On performing the Mann Whitney U test, adjusted P values reveal a significant difference in ALT (P = 0.

0348), total bilirubin (P = 0.0012) and direct bilirubin (P = 0.0024).The degree of hypoalbuminemia in males was significantly higher than in females (P = 0.

0075).Other biochemical parameters, however, did not show significant difference amongst patients based on gender.Acute kidney injury was the most prevalent condition, present in 67.2% of the patients.

Other co-morbidities were diabetes mellites, chronic liver disease, hypertension, hepatitis B and C, and hypothyroidism.Conclusion: Ultrasonography of the abdomen is an essential investigation for all patients testing positive for COVID-19.Pre-existing disease may aggravate the viral hepatic injury, thereby worsening the clinical outcome.The profiles of liver toxicity of the drugs used in the treatment read more of COVID-19 also warrant watchful monitoring of liver function.